Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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My approach to the interpretation of endometrial biopsies and curettings

Euscher E, Nuovo G J. InBokhman 68 first proposed that there were two major variants of endometrial cancer—namely type 1 the prototype of which is endometrioid carcinoma and type 2 the prototype of which is serous carcinoma. It is emphasised that in the bopsies of the other morphological features of endometritis described earlier, an exhaustive search for plasma cells is not justified.

This pseudodecidualisation is often most prominent just beneath the surface glands and is usually accompanied by an inflammatory cell infiltrate, largely comprising natural killer cells. I believe that it is useful to state this on the pathology report, especially if dealing with general gynaecologists who are not routinely occupied with the management of gynaecological neoplasms.

The endometrial glands are positive but the stroma is negative. We use cookies to give you the best possible experience. In complex hyperplasia, there is an increase in the gland to stroma ratio.

The gynaecologist may believe that a polyp is present, but histological examination shows a cyclical endometrium, often secretory in type, reflecting the fact that an abundant secretory endometrium may have a polypoid appearance.


In a postmenopausal woman with an atrophic endometrium and no focal lesion on ultrasound scan, the presence of scant endometrial tissue in an outpatient biopsy is the norm.

The morphological features of a cyclical and atrophic endometrium will not be detailed, but a few salient points are mentioned in the following sentences. Disgnosis alerts New issue alert.

Mixed endometrioid and serous carcinomas are not uncommon. Author information Article notes Copyright and License information Disclaimer. Proliferative activity is common in endometrial polyps, even in postmenopausal women. Furthermore, in biopsiee biopsy specimen from an endometrioid adenocarcinoma, it would be extremely unusual to see only myoinvasive disease in the absence of free tumour fragments.

Abstract A major proportion of the workload in many histopathology laboratories is accounted for by endometrial biopsies, either curettage specimens or outpatient biopsy specimens.

Check out the top books of the year on our page Best Books of A recent study showed that there is considerable disagreement among specialist gynaecological pathologists about what constitutes an adequate endometrial biopsy specimen.

Diagnosis of Endometrial Biopsies and Curettings: Feeley K M, Wells M. Visit our Beautiful Books page and find lovely books for kids, photography lovers and more.

Morphological features of endometrial hyperplasia In a simple hyperplasia, the normal gland to stroma ratio is maintained or there is slight increase.

Appl Immunohistochem 5 — My own view is that we should continue to use the WHO classification until further evidence emerges regarding the reproducibility, practicalities and prognostic implications of the EIN system.


Am J Surg Pathol 8 — With this artefact, the glands become moulded together and often there is tearing of the tissue around the glands, which is a clue to the artefactual nature. Disordered proliferative endometrium is common in the perimenopausal years because of anovulatory cycles.

My approach to the interpretation of endometrial biopsies and curettings

In these circumstances, successful pregnancies have ensued, although there is a high risk of subsequent recurrence of hyperplasia or carcinoma. Receive exclusive offers and updates from Oxford Academic. Purchase Subscription prices and ordering Short-term Access To purchase short term access, please sign in to your Oxford Academic account above.

Assessment of nuclear atypia is extremely subjective, resulting in marked interobserver variation, even among specialist gynaecological pathologists, in the classification of endometrial hyperplasia. Endometrial hyperplasia In my experience, various aspects endometrlal to endometrial hyperplasia commonly create problems for pathologists.

Diagnosis of Endometrial Biopsies and Curettings : Michael Mazur :

Uterine carcinosarcomas malignant mixed Mullerian tumors are metaplastic carcinomas. Lancet 1 [ PubMed ]. Kamat B R, Isacson P. The text is structured so as to present a logical approach to formulating a pathologic diagnosis from the diverse array of tissue received in the surgical pathology laboratory. J Clin Pathol 58 — Report of 89 cases and proposed classification.